Nei-like DNA glycosylase 2 selectively antagonizes interferon-β expression upon respiratory syncytial virus infection

L Pan, Y Xue, K Wang, X Zheng, A Islam… - Journal of Biological …, 2023 - ASBMB
… Our results show that NEIL2 antagonizes nuclear factor κB (NF-κB) … genome fidelity but also
for controlling immune responses. … that the role of NEIL2 is significant in the early response of …

Zebrafish NF-κB/p65 is required for antiviral responses

G Ouyang, Q Liao, D Zhang, F Rong, X Cai… - The Journal of …, 2020 - journals.aai.org
… the NF-κB family are essential for the inflammatory response as well as for innate and adaptive
immunity. NF-κB … The canonical NF-κB pathway responds to diverse immune stimulations …

Of Keeping and Tipping the Balance: Host Regulation and Viral Modulation of IRF3-Dependent IFNB1 Expression

H Schwanke, M Stempel, MM Brinkmann - Viruses, 2020 - mdpi.com
response we will briefly revisit below (see Section 3.3), wherein only a part of the IFNB1
alleles are engaged in the early response… of NF-κB is the most limiting factor of enhanceosome

How to inhibit nuclear factor-kappa B signaling: lessons from poxviruses

JB Reus, EA Rex, DB Gammon - Pathogens, 2022 - mdpi.com
… how this family of viruses can antagonize NF-κB-dependent host responses (Table 1). …
factors that is regulated by NF-κB is interferon-β (IFN-β). IFN-β plays a key role in arming cells by …

Of Keeping and Tipping the Balance: Host Regulation and Viral Modulation of IRF3-Dependent Expression.

H Schwanke, M Stempel, MM Brinkmann - 2020 - repository.helmholtz-hzi.de
… of the IFNβ response we will briefly revisit below (see … Association of NF-κB is the most
limiting factor of enhanceosome … -inducible enhancer of the interferon-β gene with tightly linked …

Rel-dependent immune and central nervous system mechanisms control viral replication and inflammation during mouse herpes simplex encephalitis

M Mancini, G Caignard, B Charbonneau… - The Journal of …, 2019 - journals.aai.org
… In children, host genetic factors play a role in determining … I IFN notably via the transcription
factors NF-κB and IRF3 (8). In … , NF-κB, and IRF3 in the protective host response to infection. …

Innate immune evasion of alphaherpesvirus tegument proteins

L Yang, M Wang, A Cheng, Q Yang, Y Wu… - Frontiers in …, 2019 - frontiersin.org
NF-κB and IRF3. The activation of these proteins finally initiates host innate immune responses,
… by stimulation of NF-κB, with recruitment of the ICP0 promoter by NF-κB activating the …

Linear ubiquitin assembly complex regulates lung epithelial–driven responses during influenza infection

PL Brazee, L Morales-Nebreda… - The Journal of …, 2020 - Am Soc Clin Investig
… play a crucial role regulating the inflammatory response and determining the severity of lung
… critical determinant of the NF-κB inflammatory response to IAV infection. Tight regulation of …

African Swine Fever Virus CD2v protein promotes β-Interferon expression and apoptosis in swine cells

S Chaulagain, G Delhon, S Khatiwada, DL Rock - bioRxiv, 2020 - biorxiv.org
… with a NF-κB inhibitor reduced CD2v-induced NF-κB-p65 … of the central role of NF-κB in
various antiviral responses, … function/s of ASFV CD2v and define a role of CD2v in induction of …

How influenza A virus NS1 deals with the ubiquitin system to evade innate immunity

LA Lamotte, L Tafforeau - Viruses, 2021 - mdpi.com
… NS1 is notably able to inhibit the host’s antiviral response through the perturbation of … inhibits
NF-κB activation by blocking the β subunit of IKK [285]. Its RBD seems to play a crucial role